Irreversible oxidations of platelet proteins after riboflavin-UVB pathogen inactivation
نویسندگان
چکیده
منابع مشابه
Economics of pathogen inactivation technology for platelet concentrates in Japan.
Residual risk of transmitting recognized and emerging blood-borne pathogens via blood transfusion in Japan persists despite advances in blood safety screening. The INTERCEPT Blood System (IBS) for platelets was developed to inactivate a broad spectrum of pathogens to reduce the risk of transfusion-transmitted infections. In this study we assessed the economic impact of the IBS on platelet trans...
متن کاملBacterial contamination of platelet concentrates: pathogen detection and inactivation methods
Whereas the reduction of transfusion related viral transmission has been a priority during the last decade, bacterial infection transmitted by transfusion still remains associated to a high morbidity and mortality, and constitutes the most frequent infectious risk of transfusion. This problem especially concerns platelet concentrates because of their favorable bacterial growth conditions. This ...
متن کاملToxicity testing of a novel riboflavin-based technology for pathogen reduction and white blood cell inactivation.
The Mirasol PRT System (Gambro BCT, Lakewood, CO) for platelets and plasma uses riboflavin and UV light to reduce pathogens and inactivate white blood cells in donated blood products. An extensive toxicology program, developed in accordance with International Organisation for Standardisation (ISO) 10993 guidelines, was performed for the Mirasol PRT system. Test and control articles for most of ...
متن کاملInduction of Nucleic Acid Damage in Viral Genomes Using Riboflavin in Combination with UV Light
Background and Aims: Despite the screening of blood donors, blood transfusion represents an ideal port of entry for blood-borne infection. Blood-borne pathogen transmission has been a concern since the earliest days of transfusion. The blood product of platelet (PLT) concentrates is still faced with the risk of bacterial and viral contaminations. Pathogen inactivation technologies offer a proac...
متن کاملInduction of Nucleic Acid Damage in Viral Genomes using Riboflavin in Combination with UV Light
Background and Aims: Despite the screening of blood donors, blood transfusion represents an ideal port of entry for blood-borne infection. Blood-borne pathogen transmission has been a concern since the earliest days of transfusion. The blood product of platelet (PLT) concentrates is still faced with the risk of bacterial and viral contaminations. Pathogen inactivation technologies offer a proac...
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ژورنال
عنوان ژورنال: Transfusion Clinique et Biologique
سال: 2020
ISSN: 1246-7820
DOI: 10.1016/j.tracli.2018.12.001